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Drug intelligence / Profile preview
OCL-1 (riboflavin)
- Development stage
- Unknown
- Lead developer
- Avivagen
- Modality
- Small Molecules
- Administration
- Ophthalmic
01
Overview
OCL-1 (also known as OCL-001) is a proprietary formulation of riboflavin (Vitamin B2) developed by OcuLuce for use in corneal cross-linking (CXL) procedures. The drug acts as a photosensitizer that, when applied to the cornea and activated by specific wavelengths of ultraviolet-A (UVA) light, generates reactive oxygen species. these reactive intermediates facilitate the formation of new covalent bonds between collagen fibrils within the corneal stroma. This process, known as collagen cross-linking, increases the biomechanical stability and stiffness of the cornea, effectively halting the progression of corneal ectatic diseases such as keratoconus and post-LASIK ectasia. OCL-1 is designed to optimize penetration and efficacy during the CXL procedure, particularly in 'epi-on' (transepithelial) or accelerated protocols.
- Other names
- Vitamin B2riboflavine
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