Drug intelligence / Profile preview

octadecyltrimethylammonium bromide

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

octadecyltrimethylammonium bromide is a synthetic quaternary ammonium surfactant consisting of a long C18 alkyl chain attached to a trimethylammonium head group with bromide as the counter‑ion. It is widely used as a cationic surfactant, emulsifier, phase‑transfer catalyst, disinfectant, and bactericide in chemical and materials applications, and in research it is employed as a small‑molecule inhibitor of the GTPase dynamin I with micromolar potency.[2][7][10][12][13][14] Its amphiphilic structure enables micelle formation and strong interactions with biological membranes, which underlie both its surfactant properties and its ability to interfere with endocytosis pathways via dynamin inhibition.[2][4][13][14]

Other names
octadecyltrimethylammonium bromidetrimethyloctadecylammonium bromidestearyltrimethylammonium bromidesteartrimonium bromide
02

Targets

DNM1 (Dynamin 1)DNM2 (Dynamin 2)

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