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octreotate
- Development stage
- Unknown
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
- Administration
- Intravenous (for Radiolabeled Forms), Subcutaneous (rarely, Non-radiolabeled Research Use)
01
Overview
Octreotate is a synthetic peptide and a somatostatin analog closely related to octreotide. It is most commonly encountered as the chelated form DOTA-octreotate (DOTA-TATE), which is used in radiopharmaceuticals for imaging and targeted therapy of neuroendocrine tumors. Octreotate binds with high affinity to somatostatin receptor subtype 2 (SSTR2), inhibiting the release of several hormones and growth factors. When labeled with radionuclides such as lutetium-177 or gallium-68, it enables both diagnostic imaging (PET/CT) and peptide receptor radionuclide therapy (PRRT) for neuroendocrine tumors by delivering targeted radiation to tumor cells expressing SSTR2.
- Other names
- octreotateDOTA-octreotateDOTA-TATE
02
Targets
SSTR2 (Somatostatin receptor type 2)SSTR3 (Somatostatin receptor 3)SSTR5 (Somatostatin receptor 5)
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