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ocular tracer for alpha-synuclein detection

Development stage: Unknown
Lead developer: Amydis
Modality: Light/Condition-Responsive Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration: Ophthalmic

Overview

A novel ocular (retinal) fluorescent tracer designed to bind specifically to aggregates of alpha-synuclein in the retina. Upon binding, the tracer emits a fluorescent signal detectable by standard ophthalmic imaging devices. This approach enables non-invasive, in vivo detection of pathological alpha-synuclein accumulation—a hallmark of Parkinson’s disease and related synucleinopathies—potentially allowing earlier diagnosis and monitoring of disease progression. The mechanism relies on selective binding to aggregated (not monomeric) forms of alpha-synuclein within retinal neurons, with subsequent fluorescence emission upon excitation. The drug is being developed as a diagnostic tool rather than a therapeutic agent.

Other names: retinal tracer for alpha-synucleinocular fluorescent tracer for alpha-synuclein

Targets

aggregated α-syn (Alpha-synuclein (α-syn))

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