odevixibat + cholestyramine

Odevixibat + cholestyramine is a combination of two agents affecting bile acid homeostasis, used for conditions involving cholestatic pruritus and lipid disorders. Odevixibat is a small molecule inhibitor of the ileal sodium/bile acid cotransporter (ASBT/IBAT), reducing bile acid reabsorption in the terminal ileum and lowering systemic bile acids, primarily indicated for pruritus in progressive familial intrahepatic cholestasis (PFIC)[1][5]. Cholestyramine is a bile acid sequestrant that binds bile acids in the gut, preventing their reabsorption and facilitating excretion, used for the management of hypercholesterolemia and pruritus associated with partial biliary obstruction[2][8]. Both drugs ultimately lower circulating bile acids, but by distinct mechanisms—odevixibat reduces absorption, while cholestyramine increases excretion. The clinical use of this combination is based on symptom control in conditions such as PFIC and cholestatic pruritus, although co-administration reduces odevixibat efficacy due to absorption interference[3][7].

Other names

cholestyramine resin