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ODI-2001
- Development stage
- Phase 1
- Lead developer
- Odimma Therapeutics
- Modality
- DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Viral Vector Vaccines → Recombinant Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Subcutaneous
01
Overview
**ODI-2001** is Odimma Therapeutics' personalized, multi-component cancer immunotherapy for advanced colorectal and pancreatic cancers. It combines patient-specific synthetic DNA encoding multiple tumor neoantigens, a Modified Vaccinia Ankara viral vector that acts as a DNA carrier and immunologic adjuvant, and the CTLA-4 checkpoint inhibitor ipilimumab to amplify T-cell priming and antitumor immune responses. ODI-2001 is being evaluated in a first-in-human Phase 1 study in metastatic or locally advanced colorectal or pancreatic cancer. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07587827))
- Other names
- ODI 2001ODI2001ODI-2001
02
Targets
CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)pMHC (Peptide-MHC complex family)
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