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ODI-2001 (Centre Georges-François Leclerc)
- Development stage
- Unknown
- Lead developer
- Odimma Therapeutics
- Modality
- DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Viral Vector Vaccines → Recombinant Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intramuscular, Intravenous
01
Overview
ODI-2001 is a personalized therapeutic cancer vaccine regimen being developed by Centre Georges Francois Leclerc. It consists of a combination of a DNA neoantigen vaccine, a Modified Vaccinia virus Ankara (MVA) viral vector adjuvant, and the checkpoint inhibitor ipilimumab (an anti-CTLA-4 monoclonal antibody). The vaccine is designed to stimulate a patient-specific immune response against tumor-specific neoantigens. The DNA vaccine provides the genetic template for the neoantigens, while the MVA vector acts as a potent viral adjuvant to enhance the immune response. Ipilimumab works by blocking the CTLA-4 checkpoint, thereby sustaining T-cell activation and overcoming tumor-induced immunosuppression. It is currently being evaluated in Phase 1 trials for metastatic or locally advanced colorectal and pancreatic cancers.
- Other names
- personalized cancer vaccine + ipilimumabDNA neoantigen vaccine + MVA + ipilimumab
02
Targets
pMHC-II (Peptide-major histocompatibility complex class II complex)Neoepitope-MHC-I (Patient-specific neoepitope-Major Histocompatibility Complex class I complex)PRR (Pattern recognition receptors)T-cell receptor specific for ODI-2001 neoepitope–MHC complex
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