ODN2395

**ODN2395** is a synthetic class C CpG oligodeoxynucleotide that acts as a **Toll-like receptor 9 agonist** in both human and murine systems. It is primarily a research-stage immunostimulatory agent and vaccine adjuvant rather than a marketed therapeutic product. By activating TLR9, ODN2395 stimulates innate immune signaling, including plasmacytoid dendritic cell and B-cell activation and induction of type I interferon-associated responses. Preclinical oncology work, including studies associated with TriSalus, has explored regional delivery of ODN2395 to liver tumors or liver metastases to reduce myeloid-derived suppressor cells, remodel the tumor microenvironment, and improve responsiveness to checkpoint blockade. The agent is also widely sold by research reagent suppliers for laboratory use only.

Brand names

Zorblive

Other names

CpG-C ODN 2395Class C CpG oligodeoxynucleotide 2395CpG-C DNA ODN 2395