Drug intelligence / Profile preview

odontocide

Development stage
Unknown
Lead developer
M & A Athanassiadis Dental
Modality
Small Molecules
Administration
Topical
01

Overview

Odontocide is a patented endodontic intracanal dressing developed by Australian Dental Manufacturing (ADM). It is a combination product consisting of 20% calcium hydroxide and 7% ibuprofen. The calcium hydroxide component achieves a high pH (over 12), which provides a potent antibacterial effect against bacteria and biofilms within the root canal system. The ibuprofen component acts as a non-selective cyclooxygenase (COX) inhibitor, functioning as a non-steroidal anti-inflammatory drug (NSAID) to reduce post-operative sensitivity and interappointment pain. The product is typically used as a temporary dressing during endodontic treatment for patients suffering from apical periodontitis or pulpal inflammation. It is TGA-certified in Australia and supplied as a paste in an 8-gram tube.

Brand names
Odontocide
Other names
calcium hydroxide + ibuprofen
02

Targets

PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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