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ODT-104 is an orally bioavailable, selective small molecule inhibitor of Janus kinase 1 (JAK1) being developed by Odyssey Therapeutics. It is designed to treat autoimmune and inflammatory diseases by selectively blocking the JAK1 signaling pathway, which is involved in the production of pro-inflammatory cytokines, while minimizing the inhibition of other JAK isoforms like JAK2 to reduce potential side effects such as anemia or neutropenia. The drug is currently in clinical development, with a primary focus on conditions such as atopic dermatitis and other inflammatory disorders.
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