Drug intelligence / Profile preview

ofloxacin + povidone-iodine

Development stage: Unknown
Lead developer: IVIEW Therapeutics
Modality: Small Molecules
Administration: Ophthalmic, Otic, Topical

Overview

Ofloxacin + povidone-iodine is a combination medication that pairs a fluoroquinolone antibiotic (ofloxacin) with an antiseptic agent (povidone-iodine). This combination leverages the complementary antimicrobial mechanisms of both components to provide enhanced effectiveness against a broad spectrum of microorganisms. Ofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, preventing DNA replication, while povidone-iodine acts as an antiseptic through the release of free iodine that disrupts microbial cell membranes and inactivates essential cellular components.

Targets

DNA gyraseTopo IV (Bacterial Topoisomerase IV)Microbial macromolecules

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