Drug intelligence / Profile preview

ofloxacin + ornidazole + lactobacillus

Development stage
Unknown
Lead developer
Kylon Remedies
Modality
Live Biotherapeutic Products → Microbiome Therapeutics, Small Molecules
Administration
Oral
01

Overview

Oflora-LB is a fixed-dose combination pharmaceutical product manufactured by Kylon Remedies, primarily used for the treatment of mixed bacterial and protozoal infections. It is commonly indicated for gastrointestinal conditions such as infectious diarrhea and dysentery, as well as pelvic inflammatory disease and certain respiratory or urinary tract infections. The formulation combines three active components: **ofloxacin**, a broad-spectrum fluoroquinolone antibiotic that inhibits bacterial DNA replication by targeting DNA gyrase and topoisomerase IV; **ornidazole**, a nitroimidazole derivative effective against anaerobic bacteria and protozoa by causing DNA strand breakage; and **Lactobacillus** (typically *Lactobacillus sporogenes* or *Bacillus coagulans*), a probiotic included to restore healthy intestinal flora and mitigate the risk of antibiotic-associated diarrhea.

Brand names
Oflora-LB
Other names
Ofloxacin + Ornidazole + LactobacillusOfloxacin + OrnidazoleOfloxacinOrnidazole
02

Targets

TOP2A (DNA topoisomerase II)Topo IV (Bacterial Topoisomerase IV)TOP1 (DNA Topoisomerase I)B-DNA (B-form DNA)DNA gyrase

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