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OIP5-AS1 small interfering RNA
- Development stage
- Preclinical
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous, Topical
01
Overview
OIP5-AS1 small interfering RNA (siRNA) is a synthetic double-stranded RNA molecule designed to silence the expression of the long non-coding RNA (lncRNA) OIP5-AS1. In the context of rheumatoid arthritis (RA) research, OIP5-AS1 has been identified as a key regulator of the miR-410-3p/Wnt7b signaling axis. By knocking down OIP5-AS1, this siRNA inhibits the excessive proliferation of fibroblast-like synoviocytes (FLS) and modulates the Wnt/beta-catenin signaling pathway, which is typically overactive in RA pathogenesis. It is primarily utilized as a research tool to investigate molecular mechanisms and validate OIP5-AS1 as a potential therapeutic target for autoimmune and inflammatory diseases.
- Other names
- siRNA targeting OIP5-AS1OIP5-AS1-siRNAOIP-5-AS1-siRNAOIP 5-AS1-siRNAOIP5 antisense RNA 1 siRNAOIP-5 antisense RNA 1 siRNAOIP 5 antisense RNA 1 siRNA
02
Targets
OIP5-AS1 (OIP5 antisense RNA 1)
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