olanzapine + paroxetine

Olanzapine + paroxetine is a combination of two pharmaceutical drugs, olanzapine and paroxetine, used together primarily in the management of major depressive disorder and other psychiatric conditions where both antipsychotic and antidepressant effects are desired. Olanzapine is an atypical antipsychotic that acts as an antagonist at dopamine D2 receptors and various serotonin receptors (including 5-HT2A/2C), while paroxetine is a selective serotonin reuptake inhibitor (SSRI) that increases synaptic serotonin levels by inhibiting its reuptake. The combination may be considered when monotherapy with either agent is insufficient for symptom control. Paroxetine inhibits CYP2D6, which can reduce the clearance of olanzapine, necessitating dose adjustments to avoid increased side effects such as sedation or cognitive impairment[1][2][3]. This combination should be used with caution due to potential pharmacokinetic interactions.