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oldenlandia diffusa extract
- Development stage
- Preclinical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Oldenlandia diffusa extract (EOD) is a botanical research compound derived from the medicinal plant *Oldenlandia diffusa* (Willd.) Roxb., a staple in traditional Chinese medicine known as 'Bai Hua She She Cao'. It is primarily investigated in academic and preclinical settings for its anticancer and neuroprotective properties. The extract contains bioactive compounds such as ursolic acid, oleanolic acid, and flavonoids. Its mechanism of action involves the selective induction of apoptosis in various cancer cell lines, including pancreatic, hepatocellular, and colorectal cancers, through the modulation of pro-apoptotic proteins like Caspase 8 and TRAILR-1. Additionally, it has been studied for its potential to alleviate cognitive impairment by targeting the BDNF and P-CREB pathways and inhibiting acetylcholinesterase.
- Other names
- Bai Hua She She CaoHedyotis diffusa extractOldenlandia diffusa (Willd.) Roxb. extract
02
Targets
CREB (Cyclic AMP response element-binding protein)BDNF (Brain-derived neurotrophic factor)Acetylcholinesterase
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