oleandomycin

Oleandomycin is a macrolide antibiotic originally isolated from Streptomyces antibioticus. It is structurally related to erythromycin but is less effective due to the absence of a 12-hydroxyl group and a 3-methoxy group. Mechanistically, oleandomycin acts as a bacteriostatic agent by binding to the 50S subunit of bacterial ribosomes, inhibiting protein synthesis necessary for bacterial survival and replication. Its spectrum of activity includes most gram-positive bacteria (such as Staphylococci and Streptococci), with limited effect on gram-negative bacteria and rickettsiae. Clinically, it has been used for infections like pyoderma, sepsis, meningitis, respiratory tract infections, urinary tract infections, and other conditions caused by susceptible organisms. Currently in the United States it is approved only for veterinary use in swine and poultry production[1][3][4][8].

Brand names

MatromycinRomicilSigmamycin

Other names

Oleandomycin phosphateOleandomycin HClOleandomycin hydrochloride