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oleanolic acid-zinc complex
- Development stage
- Preclinical
- Lead developer
- Sağlık Bilimleri Üniversitesi
- Modality
- DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules, Light/Condition-Responsive Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
**Oleanolic acid-zinc complex** is an experimental zinc coordination complex of oleanolic acid, a pentacyclic triterpenoid. In an ovalbumin-induced rat model of allergic asthma, it reduced airway inflammatory responses, including delayed-type hypersensitivity, inflammatory-cell accumulation, immunoglobulin E, cyclooxygenase-2, 5-lipoxygenase, nitric oxide, splenocyte proliferation, and pulmonary expression of several inflammatory mediators. The reported activity is preclinical and appears to reflect broad anti-inflammatory and immunomodulatory effects; no direct molecular binding target, clinical development program, marketed product, or human dosing formulation has been established.
- Other names
- OA + Znoleanolic acid-zinc complexzinc complex of oleanolic acid
02
Targets
ALOX12 (Arachidonate 12-lipoxygenase, 12S type)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)NF-κBTLR2 (Toll-like Receptor 2)TNFA (Tumor necrosis factor alpha (soluble))IL-13 (Interleukin-13)IL-17A (Interleukin-17A)IL-4 (Interleukin 4)IL-5 (Interleukin 5)
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