oligopeptide-10

Oligopeptide-10 is a synthetic bioactive peptide consisting of 15 amino acids with the sequence Phe-Ala-Lys-Ala-Leu-Lys-Ala-Leu-Leu-Lys-Ala-Leu-Lys-Ala-Leu. It is primarily utilized as an antimicrobial agent in topical cosmetic formulations for the treatment of acne. The peptide exhibits potent activity against Gram-positive bacteria, particularly *Cutibacterium acnes* (formerly *Propionibacterium acnes*), by binding to negatively charged lipoteichoic acids (LTA) on the bacterial cell wall. This binding induces osmotic imbalances and mechanical disruption of the cell membrane, resulting in bacterial cell death without the enzymatic pathways that typically lead to antibiotic resistance. It is often formulated alongside salicylic acid to provide synergistic anti-acne effects and is marketed under trade names such as Granactive Oligopeptide-10 for use in serums, cleansers, and patches.

Brand names

Granactive Oligopeptide-10

Other names

CAS 466691-40-7CAS466691-40-7CAS-466691-40-7