Drug intelligence / Profile preview

olive oil + betaine + xylitol

Development stage
Phase 3
Lead developer
Mucosa Innovations
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Topical, Buccal
01

Overview

The combination of olive oil, betaine, and xylitol is a therapeutic oral care composition, often marketed under the name Saliactive, designed to address oral dysbiosis and inflammatory conditions such as gingivitis. Delivered primarily via toothpaste or oral gels, the formulation utilizes the synergistic effects of its three main components to restore eubiosis in the oral microbiome. Olive oil acts as an emollient and barrier protector, containing phenolic compounds with antimicrobial and anti-inflammatory properties. Betaine (trimethylglycine) serves as a humectant and osmoprotectant, helping to hydrate the oral mucosa and protect cells from osmotic stress. Xylitol, a polyol, inhibits the growth of cariogenic bacteria like *Streptococcus mutans* by interfering with their metabolic pathways and helps maintain a neutral pH to prevent enamel demineralization. This combination is being evaluated for its ability to reduce clinical signs of inflammation and restore the balance of the oral ecological net.

Brand names
SaliactiveYOTUEL microbiome toothpaste
Other names
Saliactive
02

Targets

TNFA (Tumor necrosis factor alpha (soluble))IL1B (Interleukin-1 beta)

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