Drug intelligence / Profile preview

olmesartan medoxomil + hydrochlorothiazide

Development stage
Approved
Lead developer
Daiichi Sankyo
Modality
Small Molecules
Administration
Oral
01

Overview

Olmesartan medoxomil + hydrochlorothiazide is a fixed-dose combination medication used to treat high blood pressure (hypertension). It combines two active ingredients: - Olmesartan medoxomil, an angiotensin II receptor blocker (ARB), which works by selectively blocking the binding of angiotensin II to the Angiotensin II receptor type 1 (AT1) in vascular smooth muscle. This action leads to vasodilation and reduced blood pressure. - Hydrochlorothiazide, a thiazide diuretic that lowers blood pressure by increasing renal excretion of sodium and water. This combination is indicated for patients whose blood pressure is not adequately controlled with olmesartan alone. The drug reduces cardiovascular risks associated with hypertension such as stroke and heart attack. It is administered orally[1][2][5][6].

Brand names
Benicar HCTBenitec H
Other names
olmesartan/hydrochlorothiazideolmesartan medoxomil and hydrochlorothiazide
02

Targets

SLC12A3 (Thiazide-sensitive sodium-chloride cotransporter)AGTR1 (Angiotensin II Type-1 receptor)

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