OLT-201

OLT-201 is a topical gel formulation of dapansutrile (OLT1177), a selective small molecule inhibitor of the NLRP3 (nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 3) inflammasome. Developed by Olatec Therapeutics, OLT-201 is designed to treat inflammatory skin conditions by blocking the activation of the NLRP3 inflammasome, which prevents the maturation and release of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and interleukin-18 (IL-18). By targeting the innate immune system's inflammatory response at the source, OLT-201 aims to provide a localized anti-inflammatory effect with minimal systemic exposure. The drug has been primarily investigated in Phase 2 clinical trials for the treatment of mild to moderate atopic dermatitis, where it is evaluated for its ability to reduce skin lesions and associated symptoms like pruritus.

Other names

dapansutrile topical gelOLT1177 topical gelOLT-1177 topical gelOLT 1177 topical gel