olvanil

Olvanil is a synthetic small-molecule capsaicin analog (N-vanillyloleamide) that acts as a potent, non-pungent agonist of the transient receptor potential vanilloid type 1 (TRPV1) channel, with reported EC50 values in the sub-nanomolar range.[1][7][9][12] By activating and subsequently desensitizing TRPV1 on sensory neurons, olvanil produces antinociceptive and anti-hyperalgesic effects in preclinical models, with greater desensitization and vasodilatory potency than capsaicin but minimal acute nociception or CGRP release.[1][7] Olvanil also engages cannabinoid receptor systems functionally, with evidence of modulation of CB1-mediated pathways and inhibition of neuronal activity in trigeminovascular circuits, supporting investigation as an analgesic and potentially anti-migraine or anti-obesogenic agent, though it has not been approved for any indication and is currently used primarily as a research tool.[1][3][7][11][13]

Other names

N-vanillyloleamideN-(4-hydroxy-3-methoxybenzyl)oleamide(Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]octadec-9-enamide9-octadecenamide N-[(4-hydroxy-3-methoxyphenyl)methyl] (Z)N-(3-methoxy-4-hydroxybenzyl)oleamide