Drug intelligence / Profile preview

OLX703A

Development stage
Preclinical
Lead developer
Olix Pharmaceuticals
Modality
Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics
Administration
Subcutaneous
01

Overview

**OLX703A** is an investigational **GalNAc-conjugated asymmetric small interfering RNA** therapeutic from **OliX Pharmaceuticals** being developed for **chronic hepatitis B virus infection**. It is designed to target a sequence conserved across all major HBV transcripts, enabling broad knockdown of viral RNA and suppression of HBV proteins including **hepatitis B surface antigen** as well as other virologic markers such as e-antigen and HBV DNA. The program uses OliX's **GalNAc-asiRNA** platform to support hepatocyte-directed delivery, and preclinical reports indicate activity across major HBV genotypes and subtypes, with the asset remaining in preclinical or early development based on the provided information.

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