Drug intelligence / Profile preview

ombitasvir + paritaprevir + ritonavir + dasabuvir + sofosbuvir + ribavirin

Development stage
Preclinical
Lead developer
AbbVie
Modality
Small Molecules
Administration
Oral
01

Overview

This is an oral **combination regimen** consisting of six direct-acting antiviral agents—**ombitasvir**, **paritaprevir**, **ritonavir**, **dasabuvir**, **sofosbuvir**, and **ribavirin**—investigationally combined for the treatment of **chronic hepatitis C virus (HCV) infection**. Ombitasvir is an NS5A inhibitor that disrupts viral RNA replication; paritaprevir is an NS3/4A protease blocking viral polyprotein processing; ritonavir acts as a pharmacokinetic enhancer of paritaprevir by inhibiting CYP3A; dasabuvir is a non-nucleoside NS5B polymerase inhibitor targeting viral replication; sofosbuvir is a nucleotide analog NS5B polymerase inhibitor, also suppressing RNA replication; and ribavirin is a nucleoside analog with broad antiviral effects, thought to enhance virologic response. This regimen targets multiple steps in the HCV lifecycle for a synergistic antiviral effect. Such a six-drug combination is not standard nor approved under any single commercial brand but represents an advanced multi-mechanism antiviral approach to refractory or investigational cases of HCV.

02

Targets

NS5B (Hepatitis C virus non-structural protein 5B (NS5B) RNA-dependent RNA polymerase)Viral mRNA capping enzymes / cap-binding machineryEIF4E (Eukaryotic translation initiation factor 4E)NS5A (Hepatitis C virus nonstructural protein 5A (genotype 1b))NS3/4A (Hepatitis C virus nonstructural protein 3/4A serine protease)IMPDH (Inosine-5'-monophosphate dehydrogenase 1)UGT1A1 (UDP-glucuronosyltransferase 1A1)CYP3A4 (Cytochrome P450 3A4)

Beyond the preview

Go deeper on ombitasvir + paritaprevir + ritonavir + dasabuvir + sofosbuvir + ribavirin.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on ombitasvir + paritaprevir + ritonavir + dasabuvir + sofosbuvir + ribavirin.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call