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omega 3 + nigella sativa oil + deglycyrrhizinated licorice

Development stage
Preclinical
Lead developer
GSK
Modality
Small Molecules, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Oral
01

Overview

This is a combination dietary supplement containing three main ingredients: - **Omega 3 fatty acids** (commonly from fish oil), known for their anti-inflammatory and cardioprotective effects. - **Nigella sativa (black seed) oil**, standardized to thymoquinone content, which exhibits antioxidant, anti-inflammatory, immunomodulatory, and metabolic benefits. It has been shown to support gut health, immune function, insulin sensitivity, and may help modulate obesity-related inflammation[1][2][5][6]. - **Deglycyrrhizinated licorice (DGL)** is a form of licorice root extract with the glycyrrhizin removed to reduce side effects; it is primarily used for its gastroprotective properties in supporting digestive health. The combination aims to leverage the synergistic effects of these components. Omega 3s and Nigella sativa have demonstrated enhanced efficacy together in reducing inflammation markers and improving metabolic parameters such as insulin resistance[2][5]. The addition of DGL targets gastrointestinal protection. This blend is marketed as a dietary supplement for general wellness—supporting cardiovascular health, immune function, healthy inflammatory response, blood sugar regulation, gut health—and potentially adjunctive use in conditions like obesity or upper respiratory complaints[1][2][6].

Other names
omega-3 + black seed oil + DGLomega-3 + nigella sativa oil + DGLfish oil + black cumin seed oil + deglycyrrhizinated licorice
02

Targets

PRKAA1 (AMP-activated protein kinase alpha catalytic subunit isoform alpha-1)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)RELA (Nuclear Factor Kappa B Subunit p65)

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