Drug intelligence / Profile preview

omega-3-acid triglycerides

Development stage
Approved
Lead developer
BASF
Modality
Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Parenteral
01

Overview

**Omega-3-acid triglycerides** is a pharmacopeial, chemically heterogeneous fish-oil-derived lipid mixture consisting predominantly of glycerol triesters of long-chain omega-3 fatty acids, principally eicosapentaenoic acid and docosahexaenoic acid, with smaller monoester and diester fractions. It is distinct from omega-3-acid ethyl esters, omega-3 carboxylic acids, and icosapent ethyl. Pharmaceutical-grade omega-3-acid triglycerides can be used as an active ingredient in parenteral nutrition lipid formulations to provide long-chain omega-3 fatty acids when enteral administration is not feasible. Its biological effects reflect delivery of EPA and DHA, which can reduce hepatic triglyceride-rich lipoprotein production and influence fatty-acid oxidation and inflammatory lipid-mediator pathways. The broad clinical-trial excerpts referring only to \"omega-3\" supplements cannot be assumed to have used this exact triglyceride-form material.

Brand names
LovazaOmtrygVascazenOmytrgOmega-3-acid ethyl estersOmega3-acid ethyl estersOmega 3-acid ethyl estersFish OilEPA Fish Oil
Other names
omega-3 acid triglyceridesomega3 acid triglyceridesomega 3 acid triglyceridesomega-3 fatty acid triglyceridesomega3 fatty acid triglyceridesomega 3 fatty acid triglycerides
02

Targets

PPARA (Peroxisome proliferator-activated receptor alpha)PPARG (Peroxisome proliferator-activated receptor gamma)LPL (Lipoprotein lipase)DGAT1 (Diacylglycerol O-acyltransferase 1)

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