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omega-3 fatty acid (Durham VA Health Care System)
- Development stage
- Phase 1
- Lead developer
- BASF
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are being investigated by the Durham VA Medical Center as a nutritional intervention for Post-Traumatic Stress Disorder (PTSD) in veterans. These polyunsaturated fatty acids are thought to exert therapeutic effects through anti-inflammatory mechanisms and modulation of neurobiological pathways associated with stress, anxiety, and mood. The clinical research focuses on evaluating the efficacy of high-dose supplementation (titrated up to 975mg EPA and 675mg DHA three times daily) on PTSD symptoms, as measured by the Clinician-Administered PTSD Scale (CAPS), and cognitive function. This intervention represents an investigational use of a dietary supplement rather than a proprietary pharmaceutical product.
- Other names
- EPADHAeicosapentaenoic aciddocosahexaenoic acidn-3 polyunsaturated fatty acidsn3 polyunsaturated fatty acidsn 3 polyunsaturated fatty acidsfish oil
02
Targets
FFAR4 (Free fatty acid receptor 4)PPARA (Peroxisome proliferator-activated receptor alpha)PPARG (Peroxisome proliferator-activated receptor gamma)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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