Drug intelligence / Profile preview

omega-3 fatty acids (Pronova BioPharma)

Development stage
Unknown
Lead developer
BASF
Modality
Small Molecules
Administration
Oral
01

Overview

Omiga 3 is a spelling variant of omega-3 fatty acids, which are essential polyunsaturated fatty acids (PUFAs) primarily consisting of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). They are widely used as dietary supplements and are also approved as prescription pharmaceutical products (such as Lovaza, Omacor, and Omtryg) for the treatment of severe hypertriglyceridemia and the reduction of cardiovascular risk. Omega-3 fatty acids exert their lipid-lowering and anti-inflammatory effects through multiple mechanisms, including activation of peroxisome proliferator-activated receptors (PPAR-alpha and PPAR-gamma) and free fatty acid receptors (FFAR4/GPR120 and FFAR1/GPR40), as well as inhibition of diacylglycerol O-acyltransferase (DGAT) and downregulation of sterol regulatory element-binding protein 1 (SREBP-1c). In clinical trials, such as those conducted by Assiut University, "Omiga 3" has been utilized as a placebo comparator in studies evaluating other therapies (e.g., tadalafil) for lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH).

Brand names
EpanovaLovazaOmacorOmtrygTrikloVascazen
Other names
fish oilomega-3omega3omega 3omega-3 fatty acidsomega3 fatty acidsomega 3 fatty acidsomega-3 polyunsaturated fatty acidsomega3 polyunsaturated fatty acidsomega 3 polyunsaturated fatty acidsOmiga 3Omiga3Omiga-3
02

Targets

PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)FFAR1 (Free fatty acid receptor 1)FFAR4 (Free fatty acid receptor 4)LPL (Lipoprotein lipase)PPARA (Peroxisome proliferator-activated receptor alpha)PPARG (Peroxisome proliferator-activated receptor gamma)DGAT1 (Diacylglycerol O-acyltransferase 1)

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