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omega-3 lipid emulsion
- Development stage
- Unknown
- Lead developer
- Fujian Medical University
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
Omega-3 lipid emulsion is an intravenous nutritional and therapeutic intervention being studied by Fujian Medical University for the prevention of acute graft-versus-host disease (aGVHD) in patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT). The emulsion, derived from fish oil, contains high concentrations of omega-3 polyunsaturated fatty acids (PUFAs), specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). These fatty acids are hypothesized to modulate the immune system by reducing the production of pro-inflammatory cytokines and altering T-cell activation and metabolic pathways, thereby mitigating the cytokine storm associated with aGVHD. In clinical trials, it is administered as part of parenteral nutrition starting from the conditioning regimen through the early post-transplant period.
- Brand names
- Omegaven
- Other names
- omega-3 polyunsaturated fatty acidsomega3 polyunsaturated fatty acidsomega 3 polyunsaturated fatty acidsfish oil lipid emulsionomega-3 PUFAsomega3 PUFAsomega 3 PUFAs
02
Targets
FFAR4 (Free fatty acid receptor 4)PPARG (Peroxisome proliferator-activated receptor gamma)
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