Drug intelligence / Profile preview

OmegaRx

Development stage
Approved
Lead developer
University of Cincinnati
Modality
Small Molecules
Administration
Oral
01

Overview

OmegaRx is a high-purity fish oil supplement containing concentrated long-chain omega-3 fatty acids, primarily eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Developed and marketed by Zone Labs, it is designed to provide high doses of these essential fatty acids while minimizing contaminants. In clinical research led by the University of Cincinnati, OmegaRx has been evaluated in Phase 3 trials to determine its efficacy in attenuating the metabolic side effects associated with second-generation antipsychotic (SGA) use, such as quetiapine, in children and adolescents with bipolar disorder. These side effects often include significant weight gain, hypertriglyceridemia, and the development of metabolic syndrome. Omega-3 fatty acids function as agonists for peroxisome proliferator-activated receptors (PPARs), which regulate lipid metabolism and inflammatory responses, thereby potentially counteracting the cardiometabolic risks induced by SGA therapy.

Brand names
OmegaRx
Other names
omega-3 fatty acidsomega3 fatty acidsomega 3 fatty acidsfish oileicosapentaenoic aciddocosahexaenoic acidlong-chain omega-3 fatty acidsLCn-3LCn3LCn 3
02

Targets

PPARG (Peroxisome proliferator-activated receptor gamma)ALOX5 (Arachidonate 5-lipoxygenase)PPARA (Peroxisome proliferator-activated receptor alpha)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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