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Omegaven + Structolipid

Development stage
Unknown
Lead developer
Fresenius Kabi
Modality
Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Small Molecules
Administration
Intravenous
01

Overview

Omegaven + Structolipid is a parenteral nutrition combination consisting of a 10% fish oil emulsion (Omegaven) and a 20% structured triglyceride emulsion (Structolipid). This combination is administered intravenously to provide essential fatty acids, particularly omega-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In clinical research conducted by Huazhong University of Science and Technology, this regimen was evaluated for its efficacy in improving postoperative recovery, reducing systemic inflammation, and enhancing liver function in cirrhotic patients with liver cancer (hepatocellular carcinoma) undergoing hepatectomy. The omega-3 fatty acids in the formulation act as agonists for G protein-coupled receptor 120 (GPR120) and peroxisome proliferator-activated receptors (PPARs), which helps to suppress pro-inflammatory cytokine production and promote metabolic stability.

Brand names
OmegavenStructolipid
Other names
Omega-3 Fatty Acid-Based Parenteral NutritionOmega3 Fatty Acid-Based Parenteral NutritionOmega 3 Fatty Acid-Based Parenteral Nutritionn-3 fatty acid-based parenteral nutritionn3 fatty acid-based parenteral nutritionn 3 fatty acid-based parenteral nutritionOmegaven and Structolipid combination
02

Targets

PPARG (Peroxisome proliferator-activated receptor gamma)FFAR4 (Free fatty acid receptor 4)PPARA (Peroxisome proliferator-activated receptor alpha)

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