omeprazole + itopride

Omeprazole + itopride is a combination therapy consisting of two small molecule drugs used primarily for the treatment of acid-related gastrointestinal disorders such as gastroesophageal reflux disease (GERD), peptic ulcer, and functional dyspepsia. Omeprazole is a proton pump inhibitor (PPI) that suppresses gastric acid secretion by irreversibly inhibiting the H+/K+-ATPase enzyme in gastric parietal cells. Itopride is a prokinetic agent that enhances gastrointestinal motility by antagonizing dopamine D2 receptors and inhibiting acetylcholinesterase, thereby increasing acetylcholine levels in the gut. The combination aims to provide both acid suppression and improved gastric emptying, offering symptomatic relief for patients with GERD or peptic ulcers who may also have delayed gastric emptying or functional dyspepsia[1][2][4][10].

Other names

奥美拉唑 + 伊托必利