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omeprazole + losartan + caffeine
- Development stage
- Unknown
- Lead developer
- AstraZeneca
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This is a combination of three drugs used primarily as a phenotyping cocktail to assess cytochrome P450 (CYP) enzyme activity in clinical and research settings. The combination includes: - **Omeprazole**: A proton pump inhibitor that reduces stomach acid production and is used to treat conditions like GERD and stomach ulcers. - **Losartan**: An angiotensin II receptor blocker (ARB) used primarily for managing hypertension. - **Caffeine**: A central nervous system stimulant found in coffee and other beverages. When administered together, these drugs serve as probe substrates for different CYP enzymes, allowing researchers to evaluate potential drug-drug interactions and enzyme activity. This combination is part of various validated phenotyping cocktails used in clinical pharmacology research.
- Other names
- CEIBA cocktailInje cocktailKarolinska cocktail
02
Targets
ADORA1 (Adenosine receptor A1 subtype)ADORA2A (Adenosine A₂A Receptor)AGTR1 (Angiotensin II Type-1 receptor)ATP4A (Potassium–transporting ATPase alpha chain 1)ADOR (Adenosine receptors)
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