Drug intelligence / Profile preview

ONC-782

Development stage
Preclinical
Lead developer
OncoC4
Modality
CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
Administration
Intravenous
01

Overview

ONC-782 is an autologous **CAR-T cell therapy** being developed by OncoC4 for cancer treatment, particularly **solid and hematologic malignancies**. Publicly available company and partner materials identify it as a **first-in-class CD24-targeted CAR-T program**, built on OncoC4's neoCD24 targeting platform. The program remains **preclinical / IND-enabling** in public disclosures, although OncoC4 and AcroImmune previously stated that initiation of a Phase 1 investigator-initiated trial in China was expected in the second half of 2024. Detailed construct design, CAR architecture, and any assigned nonproprietary name have not been publicly disclosed.

02

Targets

NeoCD24 (Signal transducer CD24 (Tumor-associated neo-epitope))

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