Drug intelligence / Profile preview

Ond-PR1

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Ond-PR1 is a pulsatile-release oral formulation of ondansetron, developed to deliver the antiemetic agent in a controlled manner. Ondansetron is a selective serotonin 5-HT3 receptor antagonist that works by blocking the action of serotonin, a natural substance that can cause nausea and vomiting. The primary indication for ondansetron and its formulations is the prevention of nausea and vomiting associated with cancer chemotherapy, radiation therapy, and surgery. In at least one clinical study (NCT01290276), Ond-PR1 was administered as an 8 mg single oral dose in combination with methylphenidate immediate release to healthy volunteers[1][3]. The developer or manufacturer for this specific formulation has not been clearly identified in public sources.

Brand names
Ond-PR1Ond-PR-1Ond-PR 1
Other names
Ondansetron pulsatile-release formulation 1ondansetron PR1
02

Targets

HTR3A (5-hydroxytryptamine receptor 3A)

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