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Ond-PR2

Development stage: Unknown
Lead developer: Duke University Medical Center
Modality: Small Molecules
Administration: Oral

Overview

Ond-PR2 is a novel pulsatile-release formulation of ondansetron, a selective 5-HT3 receptor antagonist, being developed for the treatment of psychostimulant use disorder, including methamphetamine and cocaine abuse. Developed by Tong Lee at Duke University Medical Center, this small molecule formulation is designed for delayed absorption in the gastrointestinal tract to improve treatment compliance among patients. Ond-PR2 is primarily investigated as part of a combination therapy with immediate-release methylphenidate (MPh-IR). The pulsatile-release profile is intended to optimize the pharmacokinetics of ondansetron to better manage the neurobiological aspects of addiction. The combination treatment has demonstrated safety and tolerability in Phase Ia/Ib pharmacokinetic studies and a Phase IIa proof-of-concept clinical trial in abstinent psychostimulant abusers.

Other names: ondansetron pulsatile-release formulation 2

Targets

HTR3A (5-hydroxytryptamine receptor 3A)

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