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ONKT106
- Development stage
- Preclinical
- Lead developer
- ONK Therapeutics
- Modality
- CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
01
Overview
ONKT106 is an investigational, engineered natural killer (NK) cell therapy developed by ONK Therapeutics. This therapy involves gene-editing NK cells to enhance their cytotoxic potential, metabolic health, and persistence within the tumor microenvironment. Specifically, ONKT106 utilizes CISH (Cytokine-inducible SH2-containing protein) knockout technology, licensed from WEHI, to improve NK cell function. It is being developed for the treatment of various cancers, including blood cancers such as multiple myeloma and acute myeloid leukemia (AML), as well as solid tumors like ovarian, breast, and non-small cell lung cancer (NSCLC).
02
Targets
CD96 (T-cell surface protein tactile)HAVCR2 (T cell immunoglobulin and mucin domain-containing protein 3)SIGLEC7 (Sialic acid-binding Ig-like lectin 7)TNFRSF10A (Death receptor 4)SIGLEC9 (Sialic acid-binding immunoglobulin-like lectin 9)TIGIT (T cell immunoreceptor with Ig and ITIM domains)PDCD1 (Programmed cell death protein 1 receptor)CISH (Cytokine-inducible SH2-containing protein)TGFBR2 (TGF-β receptor type 2)CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)TNFRSF10B (DR5)
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