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ONO-4578 + letrozole + abemaciclib

Development stage: Unknown
Lead developer: Ono Pharmaceutical
Modality: Small Molecules
Administration: Oral

Overview

ONO-4578 + letrozole + abemaciclib is a **combination therapy** under investigation, consisting of ONO-4578 (a small molecule prostaglandin E2 receptor EP4 antagonist), letrozole (an aromatase inhibitor), and abemaciclib (a cyclin-dependent kinase 4/6 inhibitor)[1][4]. The therapeutic aim is to combine immune modulation (ONO-4578) with endocrine therapy (letrozole) and cell-cycle arrest (abemaciclib) for advanced or metastatic hormone receptor-positive, HER2-negative breast cancer in postmenopausal women[1][4].

Targets

OCT2 (Organic cation transporter 2)MATE2-K (Multidrug and toxin extrusion protein 2)PTGER4 (Prostaglandin E2 receptor EP4 subtype)CDK4 (Cyclin-dependent kinase 4)SLC47A1 (Multidrug and toxin extrusion transporter 1)CYP19A1 (Aromatase)CYP3A4 (Cytochrome P450 3A4)CDK6 (Cyclin-dependent kinase 6)

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