ononidis radix extract

**Ononidis radix extract** is a herbal preparation derived from the dried roots of *Ononis spinosa* L. (commonly known as restharrow root)[2][3]. The extract contains active constituents such as **isoflavones (including formononetin and its glycosides), triterpenes, deoxybenzoin derivatives, and phenolic acids**[3][4]. Its traditional and documented uses are as a mild **diuretic** and as an **adjuvant therapy for urinary tract infections, bladder inflammation, and renal gravel (kidney stones)[2][3][4]**. Mechanistically, the extract exhibits: - **Diuretic activity** by increasing urinary output and excretion of urea and chlorides[3]. - **Anti-inflammatory effects** via **antagonism of Toll-like receptor 4 (TLR4)**, inhibiting IL-8 and TNF-α release from LPS-stimulated neutrophils, modulating the expression of adhesion molecules (CD11b/CD18, CD62L), and suppression of leukotriene formation[4][2]. - **Renal human hyaluronidase-1 inhibition** by isoflavonoids contributes to the diuretic and anti-inflammatory actions[4]. Preclinical studies indicate **analgesic, diuretic, and anti-inflammatory properties; safety studies did not report toxicity**[2][3]. The extract is primarily available as herbal teas, infusions, or in combination with other botanicals in tablets and oral solutions, and is not usually marketed as a standalone pharmaceutical product[1][3].

Other names

restharrow root extractOnonis spinosa root extractOnonidis radixRestharrow root