Drug intelligence / Profile preview

opaviraline

Development stage
Discontinued
Lead developer
Sanofi
Modality
Small Molecules
Administration
Oral
01

Overview

Opaviraline is a small molecule non-nucleoside reverse transcriptase inhibitor (NNRTI) that was developed for the treatment of HIV infections. It acts by inhibiting the activity of HIV reverse transcriptase, thereby blocking viral replication. The drug reached phase II clinical trials in Germany, South Africa, and the United Kingdom but development was discontinued and it is not marketed. Opaviraline displays time-dependent pharmacokinetics with a relatively long plasma half-life suitable for once-daily dosing[2][4][5][7].

Other names
opaviralinaOpaviraline [INN]178040-94-3
02

Targets

Human immunodeficiency virus type 1 reverse transcriptase

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