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**OPF-501C** is an investigational topical zinc chloride-based treatment developed by Otsuka Pharmaceutical Factory for local control of oozing bleeding associated with cancerous skin ulcers. It was evaluated in a multicenter, open-label, uncontrolled Phase II exploratory study in Japan, in which topical application was associated with immediate suppression of oozing bleeding; the study was completed in May 2024. Development for cancerous skin ulcers was subsequently discontinued. ([jrct.mhlw.go.jp](https://jrct.mhlw.go.jp/en-latest-detail/jRCT2051230016))
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