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ophiobolin A C21-propyl ketone
- Development stage
- Preclinical
- Lead developer
- Texas State University
- Modality
- Small Molecules
- Administration
- Parenteral
01
Overview
Ophiobolin A C21-propyl ketone is a synthetic sesterterpenoid derivative of ophiobolin A, a natural product isolated from Bipolaris fungal species. It was designed to improve the metabolic stability of the parent compound by replacing the potentially labile C21-aldehyde group with a ketone. In preclinical studies, the compound was evaluated for its ability to target glioblastoma (GBM) and glioma stem cells (GSCs) through the induction of paraptosis, a form of non-apoptotic cell death. However, research indicates that the addition of the propyl group at the C21 position increases steric bulk, resulting in significantly reduced cytotoxic potency compared to the natural C21-aldehyde-containing ophiobolin A.
- Other names
- C21-propyl ophiobolin AC-21-propyl ophiobolin AC 21-propyl ophiobolin Aophiobolin A C21-Pr ketone
02
Targets
CaM (Calmodulin)PE (Phosphatidylethanolamine)PDE1 (Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase)
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