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ophiopogon japonicus root extract
- Development stage
- Preclinical
- Lead developer
- SILAB
- Administration
- Topical, Oral
01
Overview
Ophiopogon japonicus root extract is a botanical extract derived from the roots of *Ophiopogon japonicus*, a perennial plant known as 'Maidong' in traditional Chinese medicine. The extract is rich in steroidal saponins, polysaccharides (fructosans), and homoisoflavonoids. It is primarily utilized in the cosmetic industry for its moisturizing and skin-barrier-enhancing properties, particularly in products designed for eczema-prone or sensitive skin. Pharmacological research has explored its potential anti-inflammatory, antioxidant, anti-diabetic, and cardioprotective effects. One specific commercial form, AD-Resyl, is developed by SILAB for dermatological applications. It has also been investigated for its role in modulating the PI3K-AKT-mTOR/FoxO3a signaling pathway to treat obesity-associated skeletal muscle atrophy.
- Brand names
- AD-Resyl
- Other names
- Maidongsnake's beard extractJapanese lily of the valley extractOphiopogon japonicus (Lilyturf) Root Extract
02
Targets
AKT (RAC-alpha serine/threonine-protein kinase)mTOR (Mammalian target of rapamycin kinase)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)FOXO3 (Forkhead box protein O3)
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