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Opioid based anesthesia

Development stage
Unknown
Modality
Small Molecules
01

Overview

Opioid based anesthesia refers to a specific anesthetic protocol used as the control intervention in a clinical trial conducted at G.Gennimatas General Hospital. This regimen involves the administration of a combination of opioid analgesics, including a fentanyl bolus (2 mcg/kg), a remifentanil continuous infusion (0.2 mL/kg/h), and morphine (0.1 mg/kg). It is designed to provide intraoperative analgesia and suppress the surgical stress response in morbidly obese patients undergoing bariatric sleeve gastrectomy. The trial evaluates this standard opioid-based approach against an opioid-free alternative (Multimix infusion) to compare postoperative pain scores and recovery outcomes.

Other names
Opioid-based analgesiafentanyl + remifentanil + morphine
02

Targets

KOR (Kappa opioid receptor)DOR (Opioid Receptor Delta 1)MOR (Mu opioid receptor)

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