Opioid Free Anaesthesia-G.Gennimatas General Hospital-morbid obesity

Opioid Free Anaesthesia-G.Gennimatas General Hospital-morbid obesity refers to a specific multimodal anesthetic protocol developed for patients undergoing bariatric surgery, specifically sleeve gastrectomy. The regimen, often referred to as the Multimix protocol in clinical study contexts, is designed to eliminate the need for intraoperative opioids, thereby reducing opioid-related side effects such as respiratory depression and postoperative nausea and vomiting. It consists of a synergistic combination of magnesium sulfate, dexmedetomidine, lidocaine, and ketamine. These agents work together to provide analgesia, sedation, and blunting of the surgical stress response. Magnesium sulfate and ketamine act as NMDA receptor antagonists; dexmedetomidine is a selective alpha-2 adrenergic agonist; and lidocaine serves as a sodium channel blocker. This protocol is primarily investigated for its impact on postoperative pain scores and the inflammatory stress response in morbidly obese populations.

Other names

Opioid Free AnaesthesiaOFAmagnesium sulfate + dexmedetomidine + lidocaine + ketamine