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opioid-free anesthesia protocol
- Development stage
- Unknown
- Lead developer
- Peking University People's Hospital
- Modality
- Small Molecules
- Administration
- Intravenous, Topical, Paravertebral
01
Overview
This is an opioid-free anesthesia (OFA) protocol developed by Peking University People's Hospital for use in video-assisted thoracoscopic surgery (VATS) lung resection. The protocol is designed to eliminate the use of intraoperative opioids to reduce postoperative opioid-related adverse effects (ORAEs), such as respiratory depression, nausea, vomiting, and dizziness. It employs a multimodal pharmacological strategy including dexmedetomidine (an alpha-2 adrenergic agonist), lidocaine (a sodium channel blocker), and propofol (a GABA-A receptor modulator), supplemented by regional anesthesia techniques like paravertebral and serratus plane blocks using ropivacaine. This approach aims to provide adequate analgesia and stable hemodynamics while improving the quality of postoperative recovery.
- Other names
- opioid free anesthesiaOFA protocolOpioid-free Anesthesia in VATS Lung Resection
02
Targets
NaV (Voltage-gated sodium channels)ADRA2A (α2A)
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