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Opioid-Sparing Protocol
- Development stage
- Unknown
- Lead developer
- Taipei Veterans General Hospital
- Modality
- Small Molecules
- Administration
- Intramuscular, Intravenous
01
Overview
The Opioid-Sparing Protocol (OSP) is a multimodal analgesic regimen developed by Taipei Veterans General Hospital for managing postoperative pain in patients undergoing simultaneous bilateral total knee arthroplasty (TKA). The protocol is designed to provide effective pain control while minimizing the requirement for systemic opioids and reducing opioid-related complications. It consists of a combination of pharmacological agents and regional anesthesia techniques, including intravenous parecoxib (a selective COX-2 inhibitor), ultrasound-guided adductor canal blocks and periarticular injections using bupivacaine, and postoperative oral administration of celecoxib and paracetamol. In a Phase 4 clinical trial (NCT04314505), the OSP demonstrated equivalent analgesic efficacy to traditional morphine-based patient-controlled analgesia (PCA) while significantly decreasing total morphine consumption in the immediate postoperative period.
- Other names
- OSPParecoxib-based opioid-sparing protocol
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)NaV (Voltage-gated sodium channels)
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