Drug intelligence / Profile preview

OPTIFAST II

Development stage
Unknown
Lead developer
Nestlé Health Science
Administration
Oral
01

Overview

OPTIFAST II is a medically supervised total meal replacement (TMR) program and low-calorie formula diet (LCD) developed by Nestlé Health Science. The program is primarily indicated for the management of obesity and its associated comorbidities, such as Type 2 Diabetes Mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD). It typically provides approximately 800 kcal per day through nutritionally complete sachets (shakes, soups, and bars) that replace all conventional food intake during an initial intensive weight-loss phase. This significant caloric restriction induces rapid weight loss, improves glycemic control (HbA1c), and enhances insulin sensitivity. Additionally, OPTIFAST II is frequently utilized in preoperative settings to reduce liver volume and peri-organ fat, thereby improving surgical visualization and reducing perioperative risks in bariatric and major non-bariatric procedures.

Brand names
OPTIFAST IIOPTIFASTOPTIFAST 800OPTIFAST800OPTIFAST-800OPTIFAST 900OPTIFAST900OPTIFAST-900
Other names
OPTIFAST II Short programOPTIFAST formula dietOPTIFAST 800 formulaOPTIFAST800 formulaOPTIFAST-800 formula

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