Optive and Systane

This entry refers to a Phase 4 clinical trial comparison between two over-the-counter lubricant eye drop products, **Optive** and **Systane**, conducted by Innovative Medical for the treatment of dry eye syndrome. Optive, developed by Allergan, contains carboxymethylcellulose sodium and glycerin as its active ingredients. Systane, developed by Alcon, contains polyethylene glycol and propylene glycol. Both products are artificial tear formulations that function as small molecule lubricants to mechanically supplement the tear film, providing hydration and protection to the ocular surface. The trial specifically evaluated the subjective duration of action and frequency of use of these two products when used concomitantly with topical cyclosporine (Restasis) in patients with mild to moderate dry eye disease. Neither product targets a specific biological receptor; instead, they work mechanically to relieve symptoms such as dryness, irritation, and discomfort.

Brand names

OptiveSystane

Other names

Optive, Systane-Innovative Medical-dry eye syndromeOptive vs Systane Frequency of Use in Dry Eye