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Drug intelligence / Profile preview
OraCOV
- Development stage
- Preclinical
- Lead developer
- Protein Potential
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Oral
01
Overview
OraCOV is an orally administered, room-temperature stable vaccine candidate designed to protect against SARS-CoV-2 (COVID-19). Developed by Sanaria and Protein Potential in collaboration with the University of Tübingen, the vaccine utilizes the attenuated *Salmonella enterica* serovar Typhi strain Ty21a as a live bacterial vector. The Ty21a vector is genetically engineered to stably express and secrete SARS-CoV-2 antigens, specifically the spike ectodomain (eS) and the receptor-binding domain (RBD). To enhance survival in the acidic environment of the gastrointestinal tract, the vaccine incorporates a *Shigella sonnei* acid-resistance gene cassette. OraCOV is formulated as a foam-dried preparation that can be reconstituted in water and self-administered as a drink, inducing protective mucosal IgA, systemic IgG, and cellular T-cell immune responses.
- Other names
- OraCovTy21a-COVID-19 vaccineTy-21a-COVID-19 vaccineTy 21a-COVID-19 vaccineTy21a-ORACOVTy-21a-ORACOVTy 21a-ORACOV
02
Targets
SARS-CoV-2 spike
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